Specific Immunologic Unresponsiveness to Synthetic Polypeptide Antigens
- 25 January 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 139 (3552), 342-343
- https://doi.org/10.1126/science.139.3552.342
Abstract
The injection of two synthetic polypeptide antigens into adult rabbits treated with 6-mercaptopurine, or into newborn rabbits, resulted in immunological "unresponsiveness" to subsequent immunizations with these antigens. The "tolerant" animals were shown to be reactive toward the non-related antigen ovalbumin.Keywords
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