Appearance of Soluble and Gross-Reactive Complement-Fixing Antigens on Treatment of Poliovirus with Formalin.
- 1 July 1955
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 89 (3), 353-355
- https://doi.org/10.3181/00379727-89-21808
Abstract
Poliovirus in tissue culture fluid was treated with dilute formadehyde and fractionated by ultracen-trifugation. Most of the complement-fixing antigen in the active virus preparations could be sedimented at 105,000 x gravity for 2 hours. However, in the formalin-treated samples a soluble antigen appeared which remained in the supernatant fluid. The active virus preparations used were almost completely type specific in their complement-fixing reactions, but after treatment with formaldehyde, cross reactions were found between all types.Keywords
This publication has 4 references indexed in Scilit:
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