Kinetic and thermodynamic aspects of platelet adhesion from suspension to various substrates

Abstract

Kinetics of platelet adhesion from suspension to various substrates leads to Langmuir isotherm types of curves, both for suspensions in which the platelets were isolated by means of gel filtration as well as by centrifuging and washing. The level of platelet adhesion increases with increasing surface tension of the substrate. These results cannot be explained on the basis of the theoretical transport model of Ruckenstein et al. The plot of the platelet adhesion at equilibrium vs. γ_sv brings the observations in yet closer agreement with thermodynamic predictions based on free energy calculations than was found previously for the adhesion of platelets after short contact times between platelet suspension and substrate.