An intrinsically stable antibody scFv fragment can tolerate the loss of both disulfide bonds and fold correctly
Open Access
- 15 May 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 427 (3), 357-361
- https://doi.org/10.1016/s0014-5793(98)00463-3
Abstract
A fully functional cysteine‐free derivative of the intrinsically stable anti‐HER2 scFv fragment hu4D5–8 was generated by replacing the disulfide forming cysteine residues in V H and V L with the amin...Keywords
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