The Somatic Cell Genetics of Human Interferon: Assignment of Human Interferon Loci to Chromosomes 2 and 5
- 1 June 1974
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (6), 2251-2255
- https://doi.org/10.1073/pnas.71.6.2251
Abstract
A total of 40 mouse-human cell hybrids were induced with poly(I).poly(C) and with Newcastle disease virus. Ten hybrid clones produced low levels of human interferon in response to both the virus and poly(I).poly(C). Concurrent enzymic and chromosomal analysis of the hybrid clones indicated a concordant segregation of these levels of human interferon with chromosomes 2 and 5. The presence of both chromosomes 2 and 5 was necessary for interferon production; neither was sufficient alone. Based on this finding, we postulate that there are at least two asyntenic gene loci for the expression of interferon in human cells.Keywords
This publication has 18 references indexed in Scilit:
- Population studies in northern SwedenHereditas, 2009
- A new electrophoretic-autoradiographic method for the visual detection of phosphotransferasesAnalytical Biochemistry, 1973
- Assignment of Nucleoside Phosphorylase to D-14 and Localization of X-linked Loci in Man by Somatic Cell GeneticsNature New Biology, 1973
- THE LINKAGE OF GENES FOR THE HUMAN INTERFERON-INDUCED ANTIVIRAL PROTEIN AND INDOPHENOL OXIDASE-B TRAITS TO CHROMOSOME G-21The Journal of Experimental Medicine, 1973
- Evolutionary conservatism in arrangement of genetic materialChromosoma, 1973
- Accentuation of Production of Human Interferon by Metabolic InhibitorsExperimental Biology and Medicine, 1972
- The 24 fluorescence patterns of the human metaphase chromosomes - distinguishing characters and variabilityHereditas, 1971
- Genetic Analysis with Man–Mouse Somatic Cell Hybrids: Linkage between Human Lactate Dehydrogenase A and B and Peptidase BNature, 1970
- Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed RecombinantsScience, 1964
- Inhibition of interferon action by actinomycinBiochemical and Biophysical Research Communications, 1964