A study of the role of the reactive thiol group of rabbit muscle creatine kinase with a chromophoric reporter group
- 1 April 1978
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 171 (1), 269-272
- https://doi.org/10.1042/bj1710269
Abstract
Substrate- and ligand-induced conformational changes were studied in a series of thiol-modified derivatives of rabbit muscle creatine kinase that retained different amounts of enzymic activity. The results indicate that the ‘reactive’ thiol group of the enzyme is required for the conformational changes associated with formation of a ‘transition-state analogue’ complex.This publication has 12 references indexed in Scilit:
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