Polymporphism of human C-band heterochromatin. II. Family studies with suggestive evidence for somatic crossing over.
- 1 March 1975
- journal article
- Vol. 27 (2), 178-89
Abstract
An analysis of the inherited pattern of C-band heterochromatin has been made in five pedigrees containing a total of 33 offspring that were available for analysis. The majority of variants were found to be inherited; however, at least seven of the 99 variants were not present in either parent, and an additional seven differed from the parental variant by either a morphological change or the appearance of mosaicism. It is believed that the polymorphism of human constitutive heterochromatin arises from a mismatching of the repetitive DNA sequences contained in these regions with subsequent unequal crossing over. Further, the observed mosaic patterns provide suggestive evidence that such an event occurs in somatic cells as well as during meiosis.This publication has 30 references indexed in Scilit:
- New selective Giemsa technique for human chromosomes, Cd stainingNature, 1974
- SEQUENTIAL G AND C CHROMOSOME BANDINGThe Lancet, 1974
- Segregation of genetic markers in families with chromosome polymorphisms and structural rearrangements involving chromosome 1Annals of Human Genetics, 1974
- Report of the Committee on the Genetic Constitution of ChromosomeCytogenetic and Genome Research, 1974
- The nature and inheritance of an elongated secondary constriction on chromosome 9 of manCytogenetic and Genome Research, 1973
- Specific cytological recognition of the heterochromatic segment of number 9 chromosome in manExperimental Cell Research, 1972
- Populations of repeated DNA sequences in the human genomeJournal of Molecular Biology, 1972
- Antibody VariabilityScience, 1967
- The case for somatic crossing over in the mouseGenetics Research, 1966
- Cytological Evidence for Crossing-Over in vitro in Human Lymphoid CellsScience, 1964