Increase of β‐actin mRNA upon hypotonic perfusion of perfused rat liver

Abstract
β‐Actin mRNA levels in livers exposed to hypotonic perfusion (from 305 to 225 mosmol/1) for one hour are increased 2‐fold relative to albumin mRNA. Like albumin, glyceraldehyde‐3‐phosphate dehydrogenase and tyrosine aminotransferase mRNAs remain at the levels observed under normotonic conditions. The increase in β‐actin mRNA is interpreted as a cytoskeletal response due to cell swelling.