SOMATOSTATIN-28: SELECTIVE ACTION ON THE PANCREATIC 8-CELL AND BRAIN
- 1 June 1981
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 108 (6), 2391-2393
- https://doi.org/10.1210/endo-108-6-2391
Abstract
Somatostatin-28 (SS-28) is 380 times as potent as somatostatin-14 (SS-14) to inhibit acutely insulin secretion induced by arginine jLri vivo; SS-28 is only 3 times as potent as SS-14 to inhibit glucagon secretion induced by arginine. D-Trp substitution in position 28 of SS-28 increases potency to 2600 times that of SS-14 for inhibition of arginine induced insulin secretion. SS-28 is 10 and [D-Trp22]-ss-28 is 100 times as potent as SS-14 to act within the central nervous system to inhibit bombesin induced hyperglycemia. SS-28 compared to SS-14 shows pancreatic 6-cell and brain selectivity of action.Keywords
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