Correlation between fluid reabsorption and proximal tubule ultrastructure during development of the rat kidney
- 1 January 1979
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 105 (1), 11-22
- https://doi.org/10.1111/j.1748-1716.1979.tb06310.x
Abstract
Parallel functional and ultrastructural studies were performed in maturing rats to elucidate factors determining the development of proximal tubular fluid reabsorption. Three groups of hydropenic animals, which were 22-24, 28-32 and 40-45 days old, were studied. Nephron function was evaluated at the single nephron level by micropuncture technique. The ultrastructure of the developing proximal tubules was analyzed by morphometric techniques following fixation of single nephrons. Kidney wt, proximal convoluted tubule length and diameter increased during postnatal development. SNGFR [single nephron glomerular filtration rate] increased from 2.98-8.57 and to 20.5 nl/min in respective group of rats whereas proximal tubular fluid reabsorption Jv (a) increased from 0.15-0.22 and 0.34 .mu.m3/.mu.m .cntdot. s. Parallel to the functional development, the relative area of lateral and basal cell membrane increased, resulting in a constant relationship between net fluid reabsorption and the lateral and basal cell membrane area during the 4th postnatal wk, and then only a slight increase in this relation during the further development. Net fluid transport during hydropenia is determined by the amount of available lateral and basal cell membranes where the transporting enzyme for Na is located.Keywords
This publication has 31 references indexed in Scilit:
- Effect of intraluminal bicarbonate and chloride on fluid absorption by the rat renal proximal tubuleKidney International, 1976
- Ionic requirements of proximal tubular sodium transport. II. Hydrogen ionAmerican Journal of Physiology-Legacy Content, 1975
- RENAL CONTROL OF SODIUM and FLUID BALANCE IN NEWBORN INFANTS DURING INTRAVENOUS MAINTENANCE THERAPYActa Paediatrica, 1975
- DEVELOPMENT OF RENAL CONTROL OF SALT AND FLUID HOMEOSTASIS DURING THE FIRST YEAR OF LIFEActa Paediatrica, 1975
- Development of glomerular perfusion rate and nephron filtration rate in rats 17-60 days oldAmerican Journal of Physiology-Legacy Content, 1975
- Pressure Control of Sodium Reabsorption and Intercellular Backflux across Proximal Kidney TubuleJCI Insight, 1974
- RENAL RESPONSE TO AN ORAL SODIUM LOAD IN NEWBORN FULL TERM INFANTSActa Paediatrica, 1972
- The Coupling of Solute and Water Transport in EpitheliaPublished by Springer Nature ,1969
- Transtubuläre Natriumchloridflüsse und Permeabilität für Nichtelektrolyte im proximalen und distalen Konvolut der RattennierePflügers Archiv - European Journal of Physiology, 1962
- Wasserrückresorption und Ionentransport durch die Sammelrohrzellen der SäugetiernierePflügers Archiv - European Journal of Physiology, 1958