We describe an astronomical camera for the 200-in. Hale telescope using four 800 X800 Texas Instruments CCDs in an optical arrangement that allows imaging of a contiguous 1600-pixel-square region of sky. The system employs reimaging optics to yield a scale of 0.33 arcsec per pixel, a good match to the best seeing conditions at Palomar Observatory. Modern high-efficiency coatings are used in the complex optical system to yield a throughput at peak efficiency of nearly 50% (including the losses in the telescope), corresponding to a quantum efficiency on the sky of about 30%. The system uses a fifth CCD in a spectroscopic channel, and it is possible to obtain simultaneous imaging and spectroscopic observations with the system. The camera may also be used in a scanning mode, in which the telescope tracking rate is offset, and the charge is clocked in the chips in such a manner as to keep the charge image aligned with the optical image. In this way, a survey for high-redshift quasars has been carried out over a large area of sky. The instrument has produced images for the most distant clusters of galaxies yet discovered as well as spectra of the most distant galaxies yet observed.