Evidence is presented which indicates that the pressor response to injections of epinephrine and nor-epinephrine is potentiated in the anesthetized dog at blood temperatures of 27-28[degree]C. The augmented response to nor-epinephrine was greater than that for epinephrine. Evaluation of respiratory and circulatory responses to bilateral carotid occlusion and hypoxic hypoxia indicates that the hypothermic dog retains reflex activity but magnitude of the responses is less than that at normal body temperature.