Summary All strains of sarcinae (17) and lemon staphylococci (4) studied were readily dissolved by lysozyme. None of the 99 white or orange staphylococci studied showed marked susceptibility, but certain strains were dissolved by higher concentrations of enzyme. There was a definite, although not absolute, negative correlation between orange pigment, the ability to ferment mannite or produce coagulase on the one hand and susceptibility to lysozyme on the other.