Studies on New Antimetabolite N-1409

Abstract
New antimetabolite N–1409, an antagonist of l-threonine was isolated from the fermentation broth of Streptomyces. Taxonomical study on the producing strain made it a new species and named Streptomyces plumbeus n. sp. Sakai et Park after its leaden color of matured aerial mycelium. N–1409 substance was isolated as colorless needles, mp 218~220°C. Its molecular formula C12H21N4O8P·3/2 H2O was determined by elementary analysis and alkali titration. On acid hydrolysis, l-alanine, l-aspartic acid and a new phosphorus containing amino acid were obtained.