Elevated Concentrations of Ethanol in Plasma Do Not Suppress Voluntary Ethanol Consumption in C57BL Mice

Abstract

The 24-hr patterns of ethanol intake and resulting concentrations of ethanol in plasma are described for male C57BL/6J mice given free access to water and a 10% v/v solution of ethanol. Animals treated with the alcohol dehydrogenase inhibitor Cmethylpyrazole developed peak plasma concentrations of 116 ± 20 mg/100 ml, while controls given daily injections of saline exhibited peak plasma concentrations of 11± 7 mg/100 ml. Ethanol consumption as measured by total daily intake and preference was not signiflcantly different in the two groups of mice. The absence of an effect on ethanol consumption despite a tenfold difference in peak plasma levels suggests that concentrations of circulating ethanol within the range observed do not limit voluntary consumption of ethanol.