SUPPRESSION OF THE HOMOGRAFT RESPONSE BY PRETREATMENT WITH ANTITUMOR AGENTS
- 1 January 1963
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 1 (1), 65-69
- https://doi.org/10.1097/00007890-196301010-00008
Abstract
A system is described which may be employed for screening agents which suppress the immune response. The test is based on the suppression of the homograft response to leukemia L1210 and resistant sublines in pretreated C57BL mice. The aklylating agents (Cytoxan, triethylene melamine, and Melphalan) and X-irradiation exhibited marked activity in this system. 6-Mercaptopurine was moderately effective and amethopterin was relatively inactive.Keywords
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