GLOMERULAR FILTRATION RATE FOLLOWING ADMINISTRATION OF INDIVIDUAL AMINO ACIDS IN CONSCIOUS DOGS

Abstract

Normal conscious dogs were given 100 mmol glycine, L-serine, L-alanine, L-threonine, L-proline, L-glutamic acid (50 mmol), L-aspartic acid and L-valine by stomach tube. All these amino acids increased glomerular filtration rate (GFR). There was no increase in GFR following L-cystine or D-serine. The i.v. infusion of L-proline, but not glycine, caused an increase in GFR. The increase in GFR was not due to a high plasma concentration of the individual amino acids but was related to the metabolism of amino acids with production of urea. After meat and during the metabolism of amino acids a factor is probably released which reaches and acts on the kidney to cause the increase in GFR.