Abstract
A patient with systemic lupus erythematosus [LE] developed severe widespread bullae following sudden steroid withdrawal. Histologically the lesion was suggestive of leukocytoclastic vasculitis with a regenerating subepidermal bulla, but immunofluorescence on non-lesional skin revealed granular deposits of IgG and and Igm, typical of lupus erythematosus. Treatment led to resolution of the bullous eruption. Despite exacerbations of the patient''s lupus nephropathy, the blisters have not recurred. The differential diagnosis of bullous LE is discussed.