EFFECT OF CYCLOPHOSPHAMIDE ON RECOVERY FROM A LOCAL CHLAMYDIAL INFECTION - GUINEA-PIG INCLUSION CONJUNCTIVITIS (GPIC)
- 1 January 1976
- journal article
- research article
- Vol. 30 (6), 929-933
Abstract
The immune mechanism involved in the recovery from and resistance to GPIC was studied. Guinea pigs were injected with a dose of cyclophosphamide (CY) (300 mg/kg wt) that inhibits antibody synthesis. Such treatment produced a cellular depletion in the B[bone marrow-derived]-cell area without producing an appreciable change in the T[thymus-derived]-cell area of the spleen and lymph nodes. CY treatment markedly delayed the appearance of secretory immunoglobulin A antibody to GPIC in the tears, and other classes of antibodies to GPIC and sheep erythrocyte in the serum. Recovery from infection was impaired, and a subsequent injection of CY prolonged the duration of infection. B cells may play an important role in the control of this infection.This publication has 9 references indexed in Scilit:
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