DIFFERENCES IN THE BIOLOGICAL AND IMMUNOLOGICAL ACTIVITIES OF HUMAN CHORIONIC GONADOTROPHIN AFTER THE REMOVAL OF SIALIC ACID BY ENZYMIC HYDROLYSIS

Abstract

SUMMARY: Incubation of a partially purified preparation of human chorionic gonadotrophin (HCG) with neuraminidase resulted in release of free sialic acid from the substrate. The biological activity of the HCG was considerably reduced after incubation with the enzyme, but a parallel reduction in immunological activity was not observed.