Distribution patterns of neurotensin-like immunoreactive cells in the gastro-intestinal tract of higher vertebrates
- 1 February 1980
- journal article
- research article
- Published by Springer Nature in Cell and tissue research
- Vol. 205 (3), 383-395
- https://doi.org/10.1007/bf00232280
Abstract
Summary The endocrine system of the gastro-intestinal tract of selected species representing the five higher vertebrate classes was investigated with reference to occurrence and distribution of neurotensin-like immunoreactive cells. Using antibodies against C-terminal and N-terminal fragments of neurotensin and against the C-terminal sequence of xenopsin it was demonstrated that the intestine of all species studied contains endocrine, neurotensin-like immunoreactive cells. However, large differences in localization and frequency of these neurotensin-like immunoreactive cells were found. Except for a teleostean fish, neurotensin-like immunoreactive cells in the gastro-intestinal tract were more frequent in non-mammalian vertebrates than in mammals. In contrast to mammals, where the highest density of neurotensin-like immunoreactive cells was present in the ileal mucosa, in the non-mammalian vertebrates studied the corresponding cells were most abundant in the pyloric-duodenal junction. The exact mapping of neurotensin-like immunoreactive cells is presented throughout the entire gastro-intestinal tract of six species (Rattus, Coturnix, Lacerta, Rana, Xenopus, Carassius) including a quantitative evaluation of sequential serial sections.Keywords
This publication has 34 references indexed in Scilit:
- Release of neurotensin-like immunoreactivity (NTLI) from the gut in anaesthetized dogsActa Physiologica Scandinavica, 1978
- The Effects of Xenopsin on Endocrine Pancreas and Gastric Antrum in DogsHormone and Metabolic Research, 1978
- Specific localisation of neurotensin to the N cell in human intestine by radioimmunoassay and immunocytochemistryNature, 1977
- Contractile activity of synthetic neurotensin and related polypeptides on guinea-pig ileumJournal of Pharmacy and Pharmacology, 1977
- Evidence for immunoreactive neurotensin in dog intestinal mucosaLife Sciences, 1976
- Inhibition of gastric acid secretion in dogs by neurotensinLife Sciences, 1976
- Hyperglycemia and hyperglucagonemia following neurotensin administrationLife Sciences, 1976
- Isolation and structure of a new active peptide xenopsin on rat stomach strip and some biogenic amines in the skin of Xenopus laevis.CHEMICAL & PHARMACEUTICAL BULLETIN, 1975
- Isolation and Structure of a New Active Peptide "Xenopsin"on the Smooth Muscle, especially on a Strip of Fundus from a Rat Stomach, from the Skin of Xenopus laevisCHEMICAL & PHARMACEUTICAL BULLETIN, 1973
- Estimation of nuclear population from microtome sectionsThe Anatomical Record, 1946