INTERNATIONAL STUDY OF HISTOCOMPATIBILITY IN RENAL TRANSPLANTATION

Abstract

With international collaboration, data on > 2000 [human] cadaver donor transplants were collected and analyzed. In 1st transplants, the number of pretransplant blood transfusions given to the recipients correlated significantly with graft survival (P < 0.0001). No correlation of graft outcome was found with matching for HLA-A,B. HLA-DR matching was significantly correlated with outcome in the North American transplants, but not in the European subset of transplants. In 2nd transplants, HLA-DR matching and the duration of the 1st transplants correlated significantly with graft survival; there was no correlation with HLA-A,B matching or transfusions.