The effects of mannitol and urea on cerebral hemodynamics and cerebrospinal fluid pressure

Abstract

The effects of intravenous urea or mannitol on cerebral hemodynamics and cerebrospinal fluid pressure were measured in patients with recurrent brain tumors. An attempt to physically demonstrate the passage of intracranial water into the venous jugular effluent blood proved futile, though theoretic considerations make it likely that the method was not sufficiently sensitive.