Inhibition of Growth of Human Lung Adenocarcinoma Cell Lines by Anti-Transforming Growth Factor- Monoclonal Antibody
- 1 February 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 81 (3), 220-223
- https://doi.org/10.1093/jnci/81.3.220
Abstract
We previously reported that two human lung adenocarcinoma cell lines (A-549 and PC-9) produce human transforming growth factor-α (hTGF-α) and express its receptors. In the present study an exogenously added monoclonal antibody against recombinant hTGF-α inhibited growth of these cell lines in vitro. This result indicated that endogenous hTGF-α produced by the cancer cells can function as an autocrine growth factor. [J Natl Cancer List 1989;81:220–223]This publication has 9 references indexed in Scilit:
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