Quinolone Arthropathy in Animals Versus Children
Open Access
- 1 November 1997
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 25 (5), 1196-1204
- https://doi.org/10.1086/516119
Abstract
The use of quinolones in children and accumulation of data on the pharmacodynamics of these drugs have been limited and delayed by concern regarding their chondrotoxicity. A comprehensive review of the findings in animals compared with the cumulative published findings in children and adolescents (>7,000 to date) allows the conclusion that such concern is not justified. Prospective controlled studies in children are justifiable in view of a continuing lack of correlation between findings in juvenile animals and those in children and because of the selected therapeutic advantages of the current and newer quinolones.Keywords
This publication has 4 references indexed in Scilit:
- Oral ciprofloxacin vs. intravenous ceftazidime plus tobramycin in pediatric cystic fibrosis patients: comparison of antipseudomonas efficacy and assessment of safety with ultrasonography and magnetic resonance imagingThe Pediatric Infectious Disease Journal, 1997
- One-Dose Treatment with Pefloxacin for Infection Due to Multidrug-Resistant Shigella dysenteriae Type 1 in BurundiClinical Infectious Diseases, 1997
- Use of fluoroquinolones in pediatricsThe Pediatric Infectious Disease Journal, 1995
- Toxicokinetic study of norfloxacin-induced arthropathy in juvenile animalsToxicology and Applied Pharmacology, 1990