Comparative detoxication. 8. The metabolism of chlorobenzene in locusts: phenolic metabolites, a comparison with some vertebrate species
- 1 April 1960
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 75 (1), 172-179
- https://doi.org/10.1042/bj0750172
Abstract
Phenol, o-, m- and p-chlorophenol and 4-chlorocatechol have been detected in the excreta of locusts dosed with chlorobenzene. The amounts of these phenols present have been determined by isotopic-dilution procedures after dosing locusts with [14C] chlorobenzene. Determination of o-, m-and p-chlorophenol in locust excreta has also been carried out by a chromatographic-colorimetric method and the results have been compared with similar estimations on the urines of cats, ferrets, rats and rabbits dosed with chlorobenzene. The significance of the ratio of o-chlorophenol: m-chlorophenol: p-chlorophenol excreted by different species has been discussed.Keywords
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