Oxidized Low Density Lipoproteins in Patients With Transplant-Associated Coronary Artery Disease

Abstract

Abstract —The monoclonal antibody 4E6–based ELISA was used to quantify levels of oxidized LDL in plasma of 65 control subjects, 47 patients transplanted for dilated cardiomyopathy (DCM), and 60 patients transplanted for coronary artery disease (CAD). Levels of oxidized LDL were 0.68±0.039 mg/dL (mean±SEM), 1.27±0.14 mg/dL ( P <.001 versus control), and 1.73±0.13 mg/dL ( P <.001 versus control and P <.001 versus grade 0) or severe (grade 2, 3.18±0.45 mg/dL; n=10; P <.001 versus grade 0 and P <.05 versus grade 1) coronary artery stenosis. Logistic regression analysis identified three parameters that were significantly and independently correlated with posttransplant CAD: plasma levels of oxidized LDL ( P =.0001), length of follow-up ( P =.0008), and donor age ( P =.047). Thus, the present study demonstrates that plasma levels of oxidized LDL correlate with the extent of CAD in heart transplant patients and suggests that elevated levels of oxidized LDL may be a marker for CAD.