Effects of DDD on Steroid Response and Blood Flow Through the Adrenal After ACTH.

Abstract

Tech. DDD (2,2-bis(parachlorophenyl)-l,l-dichloroethane) was fed to dogs in doses of 200 mg/kg for 3 days, at the end of which time the glands were histologically normal but were not secreting 17-OHCS nor did they respond to ACTH. However, the adrenal blood flow was normal and showed a 2-3 fold increase when ACTH was administered. Similarly treated dogs were allowed 3 weeks recovery and were secreting 17-OHCS at the usual rate and showed an expected rise when ACTH was given. The adrenal blood flow was normal and responded to ACTH, yet these glands showed early histological changes characteristic of atrophy from DDD. It is demonstrated that the histological appearance, biochemical and vasodynamic state are dissociated phenomena.