Mouse embryonic chimeras: tools for studying mammalian development
Open Access
- 22 December 2003
- journal article
- review article
- Published by The Company of Biologists in Development
- Vol. 130 (25), 6155-6163
- https://doi.org/10.1242/dev.00893
Abstract
Embryonic chimeras of the mouse are well-established tools for studying cell lineage and cell potential. They are also a key part of the analysis of complex phenotypes of mutant mice. By combining embryonic stem cell technology, molecularly tagged mutations and sensitive cell lineage markers, chimeras can provide invaluable insights into the tissue-specific requirement and the mode of action of many mouse genes.Keywords
This publication has 44 references indexed in Scilit:
- Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotypeNature Biotechnology, 2003
- RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrowNature, 2002
- Cell and tissue requirements for the gene eed during mouse gastrulation and organogenesisGenesis, 2001
- Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the MouseDevelopmental Cell, 2001
- The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouseGenes & Development, 2001
- FoxH1(Fast) functions to specify the anterior primitive streak in the mouseGenes & Development, 2001
- Abnormal blood vessel development and lethality in embryos lacking a single VEGF alleleNature, 1996
- Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.Proceedings of the National Academy of Sciences, 1993
- Tracking of mouse cell lineage using microinjected DNA sequences: Analyses using genomic Southern blotting and tissue-section in situ hybridizationsDifferentiation, 1987
- Pluripotential stem cell lines as a route into the mouse germ lineTrends in Genetics, 1986