Somatomedin B: Mitogenic Activity Derived from Contaminant Epidermal Growth Factor
- 4 September 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 213 (4512), 1122-1123
- https://doi.org/10.1126/science.6973821
Abstract
The mitogenic effect of somatomedin B on human cultured glial cells was neutralized by the addition of antibodies to mouse epidermal growth factor. Somatomedin B contained epidermal growth factor--like activity, competing for binding to the epidermal growth factor receptor. It is concluded that contaminating epidermal growth factor may explain the entire mitogenic activity of somatomedin B.This publication has 10 references indexed in Scilit:
- Platelet-derived growth factor: purification and partial characterization.Proceedings of the National Academy of Sciences, 1979
- Primary structure of somatomedin B A growth hormone‐dependent serum factor with protease inhibiting activityFEBS Letters, 1978
- Purified Human Somatomedin A and Rat Multiplication Stimulating ActivityEuropean Journal of Biochemistry, 1978
- Density dependent proliferation of human glia cells stimulated by epidermal growth factorBiochemical and Biophysical Research Communications, 1976
- The NSILA-s receptor in liver plasma membranes. Characterization and comparison with the insulin receptorJournal of Biological Chemistry, 1975
- Initiation of DNA synthesis of stationary human glia-like cells by a polypeptide fraction from human plasma containing somatomedin activityExperimental Cell Research, 1975
- Isolation and characterization of polypeptides from human plasma enhancing the growth of human normal cells in cultureBiochemical and Biophysical Research Communications, 1974
- Protein a from Staphylococcus aureus. Its isolation by affinity chromatography and its use as an immunosorbent for isolation of immunoglobulinsFEBS Letters, 1972
- Somatomedin: Proposed Designation for Sulphation FactorNature, 1972
- Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born AnimalJournal of Biological Chemistry, 1962