Selective breeding for development of stomach lesions following stress in the rat.

Abstract

Following the stress of 48 hours of immobilization with food and water deprivation, 58% of the males and 68% of the females of a population were demonstrated to have developed stomach ulcers. Rats with lesions were mated and in the resulting F-sub(1) generation 79% of the males and 87% of the females developed lesions following stress. Mating of F-sub(1) generation produced offspring with 96% of the females and 82% of the males developing stomach lesions following stress. These results are taken to support the contention that hereditary factors contribute to the development of stomach lesions in rats which have been subjected to stress conditions, and corroborate previously obtained sex difference in tolerance to stress. From Psyc Abstracts 36:02:2DN15S. (PsycINFO Database Record (c) 2006 APA, all rights reserved)