EFFECT OF ECK FISTULA FORMATION, SIMPLE PORTAL OBSTRUCTION AND ‘MEAT INTOXICATION’ ON SERUM PHOSPHATASE AND DYE CLEARANCE OF ADULT DOGS

Abstract

Eck fistula formation and simple portal vein obstruction have qualitatively the same effects upon serum phosphatase and rose bengal dye clearance. Eck fistula formation consistently reduced the rose bengal dye clearance and increased the serum phosphatase of adult dogs. "Meat intoxication" regularly caused a further increase in the serum phosphatase and frequently caused a definite decline in the dye clearance of Eck fistula animals. However, meat feeding did not consistently produce any further change in the liver function tests of the simple portal vein obstructed dogs, although "meat intoxication" was produced in one such animal. The foregoing evidence indicates that neither liver function test is an index of the hepatic failure that results in the symptoms of "meat intoxication.".