Full‐term development of mouse blastomere nuclei transplanted into enucleated two‐cell embryos
- 1 May 1987
- journal article
- research article
- Published by Wiley in Journal of Experimental Zoology
- Vol. 242 (2), 147-151
- https://doi.org/10.1002/jez.1402420205
Abstract
The nuclei from four‐ and eight‐cell mouse embryos were transplanted into enucleated two‐cell embryos. It was found that such embryos not only developed to the blastocyst stage in vitro (72% and 35%), but also developed to full term (22% and 8%) after transfer to recipient mice. However, development of embryos which contained nuclei from the inner cell mass was not observed. Since the development of enucleated zygotes which contain advanced nuclei is limited (the present study; McGrath and Solter: Science, 226: 1317–1319, '84; Robl, Gilligan, Critser, and First: Biol Reprod., 34:733–739, '86), it appears that cytoplasmic factors are important for the development of nuclei from advanced cells.This publication has 16 references indexed in Scilit:
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