Renal Compensation During Mild Water Diuresis and its Inhibition by Vagotomy.

Abstract

The influence of renal artery occlusion on contralateral renal function was determined by clearance techniques in intact and vagotomized, anesthetized dogs during mild water diuresis. In intact animals, the procedure enhanced the diuresis, primarily as a result of increased free-water clearance. The compensation was not accom-paniedby significant changes in the glomerular filtration rate, effective renal plasma flow, or electrolyte excretion. After vagotomy, a compensatory renal response did not occur during renal arterial occlusion, and free-water clearance declined to negative values. These results suggest the release of antidiuretic hormone (ADH), and support the hypothesis of vagal afferent control of ADH.