Previous reported studies1on the physiology of the liver have demonstrated that (1) a characteristic group of symptoms followed by death develops after total removal of the liver; (2) these symptoms are associated with decreasing blood sugar, and the various symptoms and death occur at definite blood sugar levels; (3) the injection of glucose after symptoms develop abolishes them and restores the animal to normal, and (4) if glucose is administered after hepatectomy in amounts sufficient to maintain the blood sugar level at normal or above normal, the characteristic symptoms do not develop, but the animal lives for a variable period of time, which is always much longer than if glucose had not been administered, and dies following the development of a totally different group of symptoms. These striking and very definite results have proved that the maintenace of the normal level of blood sugar is absolutely dependent on the