11-Dehydrocorticosterone Acetate (Compound A) in Normal and Tumor Bearing Mice

Abstract

Evidence is presented that 11-dehydrocorti-costerone acetate (Compound A) has pronounced biological activity. Among these is the ability to reduce the size of the adrenal glands, of tissues related to the lymphoid system, and possibly of the accessory reproductive organs. The life expectancy of mice bearing transplantable lymphatic leukemia P1534 was increased and evidence of modification of the local lymphatic lesion was observed. Growth of the tumor mass of lympho-sarcoma 6C3HED was prevented for a short exptl. period.