Autoantibodies to a 64-Kilodalton Islet Cell Protein Precede the Onset of Spontaneous Diabetes in the BB Rat
- 22 June 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 224 (4655), 1348-1350
- https://doi.org/10.1126/science.6374896
Abstract
Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.This publication has 19 references indexed in Scilit:
- Effects of Cyclosporine Immunosuppression in Insulin-Dependent Diabetes Mellitus of Recent OnsetScience, 1984
- Workshop on the BB ratMetabolism, 1983
- Islet-Cell Antibodies and Beta-Cell Function in Monozygotic Triplets and Twins Initially Discordant for Type I Diabetes MellitusNew England Journal of Medicine, 1983
- Islet cell analysis and purification by light scatter and autofluorescenceBiochemical and Biophysical Research Communications, 1982
- Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteinsNature, 1982
- The diabetic syndrome of the ?BB? Wistar rat: Possible relevance to Type 1 (insulin-dependent) diabetes in manDiabetologia, 1982
- Autoimmunity in insulin-dependent diabetes mellitusAmerican Journal Of Medicine, 1981
- Cytotoxic Autoantibodies to Beta Cells in the Serum of Patients with Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1980
- Islet-Cell-Surface Antibodies in Juvenile Diabetes MellitusNew England Journal of Medicine, 1978
- Preparation and characterization of plasma membrane-enriched fractions from rat pancreatic islets.The Journal of cell biology, 1976