Photoradiation Therapy of Bladder Tumors

Abstract

Photoradiation therapy, in which hematoporphyrin derivative is activated by an argon-dye laser, was performed on 46 sueprficial bladder tumors in 9 patients. A fluorospectrophotometric study of biopsies from these tumors and normal mucosa revealed preferential hematoporphyrin derivative localization in malignant tissues. The tumor response was confirmed ultrasonographically in 36 stages Ta to Tl tumors. Treatment with 100-250 J/cm2 obtained complete remission in 5 of 6 patients with tumors .ltoreq. 1 cm in size. For those with tumors up to 2 cm in size the light intensity should be 300 mW/cm2 for 5-10 min or more and the accumulated energy intensity of light dose should be .gtoreq. 100 J/cm2. No patient with tumors more than 2 cm in size had a complete remission.