Role of Serotonin in the Regulation of Interferon-γ Production by Human Natural Killer Cells
- 1 February 1993
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 13 (1), 33-38
- https://doi.org/10.1089/jir.1993.13.33
Abstract
Monocytes, recovered directly from peripheral blood by counter-current centrifugal elutriation (CCE), were shown to provide two regulatory signals for induction of interferon-γ (IFN-γ) in natural killer (NK) cells in response to interleukin-2 (IL-2): an upregulating signal and an inhibitory signal. The inhibitory signal was time-dependent, irreversible, and operating on a pretranslational level, as indicated by the inability of enriched NK cells to accumulate IFN-γ mRNA in the presence of elutriated monocytes. Monocyte-induced inhibition of IFN-γ production was abrogated by the biogenic amine serotonin, acting via the 5-hydroxy-tryptamine, or serotonin (5-HT1A), subset of serotonin receptors (5-HTR). Thereby, serotonin effectively promoted IFN-γ production in the presence of monocytes. We conclude that serotonergic 5-HT1A receptors transduce signals that are required for NK cells to produce IFN-γ in response to IL-2.Keywords
This publication has 25 references indexed in Scilit:
- Cell‐to‐Cell Mediated Inhibition of Natural Killer Cell Proliferation by Monocytes and its Regulation by Histamine H2‐ReceptorsScandinavian Journal of Immunology, 1991
- Enhancement of human natural killer cell cytotoxicity by serotonin: Role of non-T/CD16+ NK cells, accessory monocytes, and 5-HT1A receptorsCellular Immunology, 1990
- Activation of natural killer cells via the p75 interleukin 2 receptor.The Journal of Experimental Medicine, 1989
- The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptorNature, 1988
- Interleukin-2-induced production of interferon-γ by resting human T cells and large granular lymphocytes: Requirement for accessory cell factors, including interleukin-1Cellular Immunology, 1988
- 5-Hydroxytryptamine Receptor SubtypesAnnual Review of Neuroscience, 1988
- (+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonistJournal of Medicinal Chemistry, 1987
- Immune interferon: a pleiotropic lymphokine with multiple effectsImmunology Today, 1985
- Response of resting human peripheral blood natural killer cells to interleukin 2.The Journal of Experimental Medicine, 1984
- 8-Hydroxy-2-(dipropylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonistJournal of Medicinal Chemistry, 1981