The Urinary Amino Acids in Relation to Calculus Disease

Abstract

The effect of the administration of amino acids in animals on the stone-forming regimen was determined. All rats were fed a diet deficient in Vitamin A for production of calculi. To one group, sodium benzoate (10 mg) and glycine (10 mg) daily to increase urinary excretion of hippuric acid, and to another group D1 glutamic acid (10 mg) were given. A third group served as controls. To mice acetazolamide (8 mg) was administered. One group received DL glutamic acid (25 mg), a second group cysteic acid (3 mg), and a third group served as controls. Glutamic acid decreased the incidence of calculi in both animals groups.