THE USE OF THE SERUM GLUTAMIC PYRUVIC TRANSAMINASE TEST FOR THE EVALUATION OF HEPATIC NECROTROPIC COMPOUNDS IN RATS
- 1 January 1962
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 40 (1), 1-6
- https://doi.org/10.1139/y62-001
Abstract
A positive correlation was established between the extent of liver necrosis, measured planimetrically, and the serum glutamic pyruvic transaminase (SGPT) level in toxic hepatitis. Intoxicated rats treated with necrotropic drugs showed significantly lower SGPT values than the control animals. The measurement of SGPT level in toxic hepatitis in rats is suggested as a method for evaluation of hepatic necrotropic compounds.Keywords
This publication has 3 references indexed in Scilit:
- Reversible Nature of Liver Cell Damage due to Carbon Tetrachloride as demonstrated by the Use of PhenerganNature, 1961
- Hepatic tests in toxicity studies on ratsToxicology and Applied Pharmacology, 1961
- A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic TransaminasesAmerican Journal of Clinical Pathology, 1957