Evidence for allelism of leaner and tottering in the mouse
- 1 February 1971
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 17 (1), 83-88
- https://doi.org/10.1017/s0016672300012040
Abstract
SUMMARY: We found thatlais located in linkage group XVIII. It is highly probable thatlaandtgare alleles, and closely, linked toEs-1. Mice of the genotypela/tgare abnormal, with clinical signs similar totg, although more severe. They develop earliest signs at about 15 days of age, similar tola, are runted but fertile and can live for months. Clinical signs are ataixa, stiffness, retarded motor activity and intermittent focal seizures. The pathological basis for these symptoms is still elusive. The three types of mice,la/la,la/tgandtg/tgare thus distinct clinically,la/tgresembling in some respect either of the other two.Keywords
This publication has 6 references indexed in Scilit:
- A neurological mutation (msd) of the mouse causing a deficiency of myelin synthesisExperimental Brain Research, 1970
- Disturbances in developmental pathways leading to a neurological disorder of genetic origin, “leaner,” in miceDevelopmental Biology, 1969
- Catalog of the Neurological Mutants of the MousePublished by Harvard University Press ,1965
- TOTTERING—A NEUROMUSCULAR MUTATION IN THE MOUSE: And Its Linkage With OligosyndactylismJournal of Heredity, 1962
- INHERITANCE OF SERUM ESTERASES HAVING DIFFERENT ELECTROPHORETIC PATTERNS: Among Inbred Strains of MiceJournal of Heredity, 1962
- On the Regulation of Gene ActivityCold Spring Harbor Symposia on Quantitative Biology, 1961