Effects of Adrenalectomy and Glucocorticoid Therapy on Enzyme Activities in Mammary and Adipose Tissues from Lactating Rats

Abstract

Several mammary and adipose enzymes were measured in normal, adrenalectomized, adrenalectomized cortisol-treated, and intake-restricted lactating rats. Acetyl-CoA carboxylase, lipoprotein lipase and triglyceride synthetase complex activities in mammary tissue were unchanged by intake restriction, decreased by adrenalectomy, and increased by glucocorticoid-replacement therapy. Malic dehydrogenase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and lipoprotein lipase activities in adipose were unchanged after adrenalectomy.