Behavior of radiozinc in rat plasma
- 30 April 1962
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 202 (5), 926-930
- https://doi.org/10.1152/ajplegacy.1962.202.5.926
Abstract
This series of studies was undertaken to determine the behavior of Zn65 when injected intravenously as the inorganic ion. A clearance curve for Zn65 similar to those of other workers was obtained. It was found that the decrease in clearance and distribution of Zn65 was not in direct proportion to the decrease in specific activity. Upon extraction of loosely bound zinc from plasma with dithizone-acetone virtually all of the injected Zn65 could be removed up to 1 hr after intravenous injection. However, extraction of the unbound zinc ion demonstrated that more than 90% of the Zn65 is bound to protein within the first 3 min after addition of Zn65. Dialysis of Zn65 against plasma protein showed the Zn65 ion is removed by plasma from solution by direct binding to nondialyzable plasma components. Irradiation of rats with supralethal dosages of X ray followed by subsequent injection of Zn65 demonstrated that clearance of Zn65 from plasma is unaffected by this major alteration of the metabolic state of the animal.Keywords
This publication has 1 reference indexed in Scilit:
- The behaviour of zinc and radio-zinc in the ratBiochimica et Biophysica Acta, 1956