Effects of the non-steroidal anti-inflammatory drug benoxaprofen on leucocyte migration
- 1 September 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 31 (1), 366-370
- https://doi.org/10.1111/j.2042-7158.1979.tb13524.x
Abstract
Possible modes of action of the anti-inflammatory drug, benoxaprofen, have been explored. The drug caused inhibition of leucocyte migration, principally of mononuclear cells into the pleural cavity of rats undergoing carrageenan-induced pleurisy. Evidence was obtained from in vitro leucocyte migration and chemotaxis models that the drug acted directly on the mononuclear cells rather than by inhibition of chemotactic factors.This publication has 11 references indexed in Scilit:
- Disposition and Metabolism of Benoxaprofen in Laboratory Animals and ManXenobiotica, 1978
- The effect of bovine serum albumin on the in vitro inhibition of chemotaxis by anti-inflammatory agentsInflammation Research, 1977
- The pharmacology of benoxaprofen (2-[4-chlorophenyl]-α-methyl-5-benzoxazole acetic acid), LRCL 3794, a new compound with anti-inflammatory activity apparently unrelated to inhibition of prostaglandin synthesisJournal of Pharmacy and Pharmacology, 1977
- Separate anti-inflammatory effects of indomethacin, flurbiprofen and benoxaprofenJournal of Pharmacy and Pharmacology, 1977
- Some effects of non-steroidal anti-inflammatory drugs on leucocyte migrationInflammation Research, 1976
- A histopathological and pharmacological analysis of the mode of action of non‐steroidal anti‐inflammatory drugsThe Journal of Pathology, 1971
- Effects of anti-inflammatory drugs on the stability of rat liver lysosomes in vitroBiochemical Pharmacology, 1971
- Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like DrugsNature New Biology, 1971
- The effect of anti-inflammatory drugs on the enzymic activity of a rat liver granular fraction which increases vascular permeabilityBiochemical Pharmacology, 1968
- In vitro Cell Migration as a Model for Delayed Hypersensitivity.Experimental Biology and Medicine, 1962