Preparation and in vivo studies of a new drug delivery system
- 1 February 1984
- journal article
- research article
- Published by Springer Nature in Applied Biochemistry and Biotechnology
- Vol. 10 (1-3), 263-265
- https://doi.org/10.1007/bf02783760
Abstract
Polyhexylcyanoacrylate nanoparticles have been prepared with vincamine as the model drug. These particles had an average size of 200 nm and adsorbed approximately 435 of vincamine. The adsorption of vincamine to nanoparticles modified the distribution of vincamine in tissues. After iv injection the distribution volumes were increased in comparison with an aqueous solution of drug. In comparison with an aqueous solution of drug, the absolute bioavailability of vincamine was also increased after an oral administration of nanoparticles.Keywords
This publication has 2 references indexed in Scilit:
- Tissue Distribution of Antitumor Drugs Associated with Polyalkylcyanoacrylate NanoparticlesJournal of Pharmaceutical Sciences, 1980
- [Perspective on the use of microdisperse forms as intracellular vehicles].1978