Intestinal Permeability to Inert Sugars and Different-Sized Polyethyleneglycols in Children with Celiac Disease

Abstract

Intestinal permeability was measured in a total of 42 children, 29 of whom had celiac disease. The celiac children were studied at presentation, during gluten-fre diet, and/or at gluten challenge. The permeability was assessed by oral lacutlose/L-rhamnose in all 42 children and also by different-sized polyethylene glycols (PEG) in 36 children. Results were compared with the findings of small intestinal biopsy. The mean of the permeability tests in children with enteropathy was significantly abnormal compared with the result in children with a normal mucosal morphology. The lacutlose/L-rhamnose test and the PEG test gave equivalent results in the sance child. In the celiac child en abnormal permeability properties at presentation normalized during gluten-free diet and reappeared during gluten challenge. It is concluded that measurement of intestinal permeability may be a valuable tool in monitoring children with celiac disease, preferably when serial measurements are available in the same child.