1) This study was undertaken to ascertain the difference between, the control group (0.75mg/day/rat) and experimental groups (7.5 and 75mg/day/rat) regarding the effect of vitamin E. 2) Mother's body wt. was remarkably decreased in the 75mg/day/rat-group. Pregnancy rate was slightly lower in the 7.5mg/day/rat-group and was 50% in the 75mg/day/rat-group. 3) Implantation condition of pregnant mothers was slightly less in the experimental group. 4) Slight ossification retardation in fetus of occipital bone and sternebrae was generally observed in the experimental group. 5) Abnormalities in appearance and skeleton were not observed. 6) Effect of vitamin E on the fetus was induced in the 75mg/day/rat-group, but abnormalities in appearance were not observed.