CORRELATION OF INSULIN REQUIREMENTS WITH THE CONCENTRATION OF INSULINBINDING ANTIBODY IN TWO CASES OF INSULIN RESISTANCE

Abstract

A correlation between the concentration of insulin-binding antibody and the degree of insulin resistance was demonstrated in 2 patients with insulin-resistant diabetes. Both patients had high antibody titers during the acute phase of insulin resistance. The titers decreased concomitantly with a decrease in the insulin requirement. These findings suggest that in some cases insulin-binding antibodies may account for insulin resistance.