Effect of Chlorpromazine on Survival From a Single Massive Hemorrhage
- 1 June 1956
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 185 (3), 505-509
- https://doi.org/10.1152/ajplegacy.1956.185.3.505
Abstract
In dogs subjected to a single hemorrhage equivalent to 4% of the body weight, 2 and 5-mg/kg doses of chlorpromazine administered 30 minutes before hemorrhage and 2 mg/kg given immediately after hemorrhage exerted a deleterious effect in terms of survival. When the drug was given 5 hours before hemorrhage no injurious effect on survival was observed. The reduced frequency of survival appeared to be related to the autonomic blocking activity of the chlorpromazine.Keywords
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